Drug-Induced Pulmonary Eosinophilia

Drug-Induced Pulmonary Eosinophilia:

• Drug associated transient pulmonary infiltrates, with an elevated eosinophil count.
• Clinical spectrum is variable.

Clinical Spectrum:

• Acute picture - simulating hypersensitivity pneumonitis - ie cocaine.
• Insidious onset picture - chronic symptoms & dyspnoea - ie nitrofurantoin.
• Loeffler-like picture - ie penicillin.
• Eosinophilic vasculitis picture - ie zafirlukast.

Drug Causes (Antibiotics):

• Ampicillin
• Minocycline
• Nitrofurantoin
• Penicillin
• Pentamidine (aerosolized)
• Sulfonamide

Drugs Causes (Other):

• Chlorpropamide
• Crack Cocaine
• L-tryptophan
• NSAIDs
• Paracetamol (Acetaminophen)
• Ranitidine
• Zafirlukast

Tags: Antibiotics - Cocaine - Drug-Induced Pulmonary Eosinophilia - Eosinophilic vasculitis - Nitrofurantoin - Pneumonitis - Pulmonary Eosinophilia - Pulmonary Infiltrate
Posted by Medicalchemy
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