Lymphocytic Interstitial Pneumonitis (LIP)

LIP General Facts:

• Lymphocytic Interstitial Pneumonitis (LIP) is a lymphoproliferative lung disorder.
• Pathologically there is diffuse infiltration of lymphocytes, plasma cells & immunoblasts along lymphatics & in alveolar septae.
• Diagnosis - open lung biopsy, with above histological features & infection excluded.

LIP Clinical Features:

• Uncommon.
• No obvious cause apparent.
• Presents with cough, dyspnoea & fever.
• Tends to occur earlier rather than later in the course of HIV infection.

LIP Radiological Examination:

Chest Xray:

• May be normal.
• Typically reveals reticular or nodular infiltrates.
• Infiltrates predominantly basilar in location.

CT Chest:

• Peribronchovascular nodules (2-4 mm in diameter).
• Ground glass opacities may be present.

LIP Prognosis:

• Varies from benign course (with spontaneous resolution or stabilisation) to respiratory failure.

Tags: HIV infection - LIP - Lymphocytic Interstitial Pneumonitis - Open Lung Biopsy

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